Characterization of the human SLC30A8 promoter and intronic enhancer
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چکیده
منابع مشابه
Characterization of the human SLC30A8 promoter and intronic enhancer.
Genome-wide association studies have shown that a polymorphic variant in SLC30A8, which encodes zinc transporter-8, is associated with altered susceptibility to type 2 diabetes (T2D). This association is consistent with the observation that glucose-stimulated insulin secretion is decreased in islets isolated from Slc30a8 knockout mice. In this study, immunohistochemical staining was first used ...
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The SLC30A8 gene encodes the zinc transporter ZnT-8, which provides zinc for insulin-hexamer formation. Genome-wide association studies have shown that a polymorphic variant in SLC30A8 is associated with altered susceptibility to Type 2 diabetes and we recently reported that glucose-stimulated insulin secretion is decreased in islets isolated from Slc30a8-knockout mice. The present study examin...
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The invariant chain gene intronic enhancer shows homology to class II promoter elements.
Coordinate expression of MHC class II proteins and the class II-associated invariant chain (Ii) is important for proper MHC class II functioning in Ag processing and presentation. The coordinate regulation of these genes results, in part, from the sharing of transcriptional regulatory regions between MHC class II and Ii genes; the Ii has previously been shown to have an upstream enhancer closel...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2011
ISSN: 0952-5041,1479-6813
DOI: 10.1530/jme-11-0055